This present article aims to analyze Math and Science students performance from Brazilian universities based on the National Exam for the Assessment Of Student Performance grades (ENADE) taken in 2014. Nevertheless, these variables were analyzed by multiple linear regression techniques and by the stepwise method. Lastly, it was perceived that variables such as course, course time, institution, gender, deficiency, and the institutions city are relevant and influential when it comes of students performance in the fields of Math and Science that took part on the exam ENADE.