Toward Multicenter Skin Lesion Classification Using Deep Neural Network With Adaptively Weighted Bal

Recently, deep neural network-based methods have shown promising advantages in accurately recognizing skin lesions from dermoscopic images. However, most existing works focus more on improving the network framework for better feature representation but ignore the data imbalance issue, limiting their flexibility and accuracy across multiple scenarios in multi-center clinics. Generally, different clinical centers have different data distributions, which presents challenging requirements for the network’s flexibility and accuracy. In this paper, we divert the attention from framework improvement to the data imbalance issue and propose a new solution for multi-center skin lesion classification by introducing a novel adaptively weighted balance (AWB) loss to the conventional classification network. Benefiting from AWB, the proposed solution has the following advantages: 1) it is easy to satisfy different practical requirements by only changing the backbone; 2) it is user-friendly with no tuning on hyperparameters; and 3) it adaptively enables small intraclass compactness and pays more attention to the minority class. Extensive experiments demonstrate that, compared with solutions equipped with state-of-the-art loss functions, the proposed solution is more flexible and more competent for tackling the multi-center imbalanced skin lesion classification task with considerable performance on two benchmark datasets. In addition, the proposed solution is proved to be effective in handling the imbalanced gastrointestinal disease classification task and the imbalanced DR grading task.